TDM-1

Topic: TDM-1

Posted on: November 24, 2016

Patient no 3
A 45 years old man is brought to the emergency by his wife. He has ingested some
unknown medication in a suicide attempt. The patient is disoriented in time. His
temperature is 1030 F, blood pressure is 120/85 mmHg, pulse is 100/ min (irregular)
and respiration ate is 22/min. The skin is flushed and dry. Dilated pupils and muscle
twitching are also noted on physical examination. ECG reveals prolonged QRS
complexes.

  • Serum ALT : 24 U/L
  • Arterial Blood Gases: normal acid base status.

a. Name the drug which is the most likely cause of intoxication?

b. Name the analytical technique used to confirm the presence of the drug in the
blood.

a. Tricyclic antidepressant (TCA)

b. Liquid Chromatography-Mass Spectrometry (LC-MS)
Ref No 3
Tricyclic antidepressant poisoning
www.UpToDate.com 2015

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